Macular Degeneration Update
Age Related Macular Degeneration (AMD) & latest
Treatment with Intraviteal injections of LUCENTIS & AVASTIN (anti VEGF). Exudative age related macular degeneration (wet
ARMD) continues to be a common blinding retinal disorder. Laser treatment for
wet ARMD often is not possible or worsens the patient's vision. Unfortunately,
the majority of leakages are occult or poorly defined choroidal neovascular
membranes (CNVM) which are located under the center of the macula. These lesions
respond the poorest to traditional laser therapy. The new treatments of anti-VEGF
for exemple LUCENTIS or AVASTIN, might have a great benefit to patients
with leakage located directly under the
macula. So far, Dr. T.S. Melki has performed over 500 of these injections
(2007).
Limited Retinal Translocation
can move the retina inferiorly so
that small classic (well defined) submacular CNVM can be moved "out" of the
central macula prior to laser. Retinal surgeons now have the technical
capability to perform translocation surgery. The CNVM can then be treated post-operatively
while hopefully preserving the central macula. Limited retinal translocation is
a reasonable procedure to consider for small classic submacular CNVM in a
attempt to prevent further vision loss. Significant complications
can occur following retinal translocation surgery.
Photodynamic Therapy (PDT)
will allow for the treatment of subfoveal CNVM with less
damage to the overlying retina. Hopefully, patients will experience less vision
loss following PDT treatment. PDT requires the injection of a photosensitive dye
prior to laser therapy. The preliminary results for PDT are encouraging when the
majority of the leakage is classic (well defined). Unfortunately, in the same
clinical trial, PDT was not proven visually beneficial in patients when the
majority of the lesion was occult (poorly defined). Dr. T.S. Melki currently
(2007) rarely offers this therapy option.
Transpupillary Thermotherapy (TTT)
is an alternative therapy for patients with occult (poorly defined) subfoveal
leakage. TTT utilizes the diode laser with an enlarged spot size and extended
treatment time to treat subfoveal CNVM with less overlying retinal damage. TTT
avoids the use and expense of the dye used in PDT. The preliminary results for
TTT indicate the ability to stabilize vision loss in the majority of patients
treated. TTT is already FDA approved. A large clinical trial of TTT is currently
being organized. We are currently utilizing TTT in our offices for
patients with otherwise untreatable subfoveal occult leakage.